The Dutchman, who made the mistake of entering the wrong dressing room upon his return to the Emirates Stadium, spearheads the visitors' attack alongside Wayne Rooney.
Arsenal, who can move four points clear of fifth-placed Tottenham Hotspur with a win, have also made two alterations since their last outing.
Arsenal: Szczesny, Sagna, Mertesacker, Koscielny, Gibbs, Arteta, Ramsey, Rosicky, Cazorla, Walcott, Podolski
Subs: Mannone, Vermaelen, Jenkinson, Monreal, Wilshere, Oxlade-Chamberlain, Gervinho
Man United: De Gea, Rafael, Ferdinand, Evans, Evra, Valencia, Carrick, Jones, Nani, Rooney, Van Persie
Subs: Lindegaard, Anderson, Giggs, Hernandez, Cleverley, Kagawa, Buttner