Phil Jones has also been named in the starting lineup in place of Chris Smalling, who substitutes.
Meanwhile, the Latics are unchanged from the side that lost to Chelsea at the weekend.
Wigan: Al Habsi; Alcaraz, Boyce, Caldwell, Figueroa; Maloney, Beausejour, McArthur, McCarthy; Moses, Di Santo
Subs: Pollitt Crusat, Ben Watson, Gomez, Sammon, Diame, Stam
Man Utd: De Gea; Evra, Ferdinand, Evans, Jones; Carrick, Giggs, Young, Valencia; Rooney, Hernandez
Subs: Amos, Smalling Park, Nani, Welbeck, Cleverley, Pogba