The Magpies won 1-0 at Old Trafford in December in the first of consecutive home defeats for David Moyes and even darker times have followed for the United boss.
However, a spirited draw against European kings Bayern Munich in the first leg of their Champions League quarter-final on Tuesday proved that the Red Devils can still mix it with the best on their day.
United fans will tell you that their day has not come around very often this season and that is why they are only eight points above Newcastle, compared to 41 as they were at the same stage last term.
Moyes can put to bed any fears that the Tyneside outfit could yet leapfrog his side in the table with victory this weekend, although some players may be rested ahead of the huge trip to Germany on Wednesday.
Juan Mata, who scored his first United goal in the 4-1 success over Aston Villa, is ineligible for continental competition so should be recalled, and Patrice Evra is available after serving a European suspension.