While the North-West outfit would traditionally be favourites for the encounter, some are tipping Arsenal to snatch all three points on away turf following their impressive start to the season.
It's a campaign of transition for United following the retirement of Sir Alex Ferguson in the summer and the arrival of former Everton boss David Moyes.
Ten games into the Premier League season and there are already eight points between the two clubs in the table, with Arsenal soaring at the top and United sitting seven places below.
The Gunners head into the clash five points clear at the top following last Saturday's 2-0 win over Liverpool at the Emirates, while United have overcome an inconsistent start to grab two league wins on the bounce.
United also managed to secure an 8-2 hammering of the North London outfit in 2011 under the guidance of Ferguson.
Manchester United: LLWDWW
Possible starting lineups
Manchester United: De Gea; Rafael, Vidic, Evans, Evra; Valencia, Carrick, Cleverley, Janzuaj; Rooney, Van Persie
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Flamini, Arteta, Ramsey, Cazorla, Ozil; Giroud
Sports Mole says: 2-2