Arsene Wenger's side are the division's in-form team going into the match, having won five and drawn one of their last six games to reignite their hopes of qualifying for next season's Champions League.
United's 3-0 victory over Aston Villa on Monday evening sealed the title for the Old Trafford outfit with four games of the season remaining.
Sunday's game will see United striker Robin van Persie returning to the Emirates Stadium for the first time since leaving Arsenal last summer.
Arsenal could be without Mikel Arteta after the midfielder picked up an ankle injury against Fulham, with Jack Wilshere likely to be recalled. Olivier Giroud will sit out the first game of his three-match ban after his sending-off at Craven Cottage, with Theo Walcott or Lukas Podolski in line to replace him up front.
Man Utd: WWLWDW
Possible starting lineups
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Ramsey Wilshere, Rosicky, Cazorla, Walcott; Podolski
Man Utd: De Gea; Rafael, Vidic, Ferdinand, Buttner; Cleverley, Jones, Kagawa, Nani; Rooney, Van Persie
Sports Mole says: 1-1