The arch rivals go head to head at Anfield, with manager David Moyes due to experience his first encounter between the two clubs as manager of the Red Devils.
"I can't wait for the game," Welbeck told the club's official website. "Ever since I've been at the club, coming through the Under-9s to 15s, 16s, youth team and reserves - no matter what the situation is, it's massive.
"Obviously we'll want to go there and win but it's going to be another intense game and I think the whole club is really looking forward to it."
Liverpool have a 100% record in the Premier League so far after claiming two 1-0 victories over Stoke City and Aston Villa respectively, while United head to Anfield on the back of one win and one draw following their goalless bout with Chelsea.