Vidic, who has spent eight months on the sidelines with a knee injury, has admitted that he could not wait to run out in front of the club's home supporters.
Vidic told United Review: "I've been waiting for it a long time. I've already played Everton but I am looking forward to playing at Old Trafford.
"It's always nice to run out in front of 75,000 supporters at home."
The Serbian international is expected to line up in central defence when Manchester United play Fulham on Saturday.