The Red Devils secured their 20th Premier League title after brushing aside the Villans 3-0 courtesy of a hat-trick from the Dutch international, which included a stunning volley to double the lead.
The 29-year-old feels that the significance as well as the brilliance of the goal makes it his best for United.
"It is hard," Van Persie told MUTV. "Maybe if you look at the day, the occasion and the importance of the goal it was my best one.
"It was a great pass from Wayne [Rooney] for a start. He had to spot my run because I went in front of Ron Vlaar. It was straight into my path. I was counting my steps. The only thing I had to do was time it right and keep my body straight, level with the ball.
"You need to be a bit lucky with those goals because most of them go over or wide. That didn't, which was a big relief."
Van Persie is the Premier League's top scorer this season with 24 goals.