The Frenchman was part of the Blackburn Rovers team that collected a 3-2 win at Old Trafford last season.
With that in mind, the 23-year-old has urged his teammates to have a positive attitude against the Red Devils.
"It is one game and people may not give us much chance on Saturday. Similarly nobody gave Blackburn a chance when we went there last season, and look what happened that day," he told the club's official website.
"We have performed well this season and picked up points from games where people may not have thought we would get anything.
"We are moving in the right direction and I am really enjoying being a part of it all."
N'Zonzi joined the Potters from Rovers during the summer transfer window.