The Red Devils trail the Londoners by 10 points in the race for the title after eight matches this season, and Hoddle feels that Louis van Gaal can throw caution to the wind and attack Jose Mourinho's side due to their current position in the top flight.
Hoddle wrote in the Daily Mail: "So far they haven't been as aggressive or ruthless as Sir Alex Ferguson's teams. That's what I'm waiting to see from them today.
"Given United don't really have the players to be cautious, it would not surprise me if Van Gaal goes with a diamond formation, with two up front, so he can get [Robin] Van Persie, [Radamel] Falcao, [Angel] Di Maria and [Juan] Mata into the team.
"With Diego Costa very doubtful and Loic Remy injured, Chelsea may have to start with Didier Drogba or Andre Schurrle up front, and if they do, this is United's opportunity to take the game to Chelsea."
Hoddle spent the final two years of his playing career at Stamford Bridge before becoming manager in 1993.