Aged just 17, the boy from Belfast made his debut for United during a 1-0 First Division victory over West Bromwich Albion on September 14, 1963.
He'd go on to make over 350 appearances for the North West outfit and despite a series of well documented off-the-field problems, he is regarded by many to be the best player to have ever pulled on a red shirt.
To mark the upcoming occasion, Sports Mole has picked out six of his best moments from his 11 years with United, including video highlights.
Vs. Sheffield United, 1971
Vs. Benfica, 1968
Vs. Real Madrid, 1968
Vs. Tottenham Hotspur, 1971
Vs. Northampton Town (six goals), 1970
Vs. West Ham United (hat-trick), 1971