The Spanish goalkeeper, who made his league debut in the 3-1 defeat to United at Old Trafford in December, believes that West Ham must approach the game with the correct mentality to beat the champions.
"It's an important game and a difficult game. I made my league debut against Manchester United at Old Trafford and since then we have gained more confidence, that's important," Adrian told West Ham TV.
"I think that with us playing at home it will make it a good game and we will try to win the three points.
"It was difficult to make my debut there, but here every match is difficult and you need the right mentality and concentration in every game because nobody gives you the three points for nothing."
The Hammers are currently 12th in the Premier League.