Manchester City will make the trip to Wigan Athletic in the FA Cup fifth round, while Manchester United will travel to Huddersfield Town or Birmingham City.
Premier League leaders Manchester City have been handed a trip to Wigan Athletic in the FA Cup fifth round.
City kept their hopes of the quadruple alive with a 2-0 win over Cardiff City on Sunday, and Pep Guardiola's side will now travel to fellow North-West outfit Wigan, who are sitting top of the League One table.
Manchester United will travel to either Huddersfield Town or Birmingham City, while Tottenham Hotspur or Newport County have been given an away game at either Millwall or Rochdale.
Chelsea are at home to Hull City, with League Two side Coventry City being handed a journey to the south coast to play Brighton & Hove Albion.
West Bromwich Albion and Southampton will meet at The Hawthorns, while Leicester City have been handed an encounter with Sheffield United at the King Power Stadium.
Swansea City boss Carlos Carvalhal will make an early return to Sheffield Wednesday, providing that the Welsh club overcome Notts County in next week's replay.
Sheffield Wednesday vs. Notts County/Swansea City
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West Bromwich Albion vs. Southampton
Chelsea vs. Hull City
Leicester City vs. Sheffield United
Huddersfield Town or Birmingham City vs. Manchester United
Millwall or Rochdale vs. Newport County or Tottenham Hotspur
Brighton & Hove Albion vs. Coventry City
Wigan Athletic vs. Manchester City