The main beneficiary from the Lingard and Martial layoffs is Romelu Lukaku, who should be brought back into the side on Monday alongside Marcus Rashford, who has six goals in his last 10 matches.
A knock picked up by Sanchez could curtail his involvement, however, meaning a possible 4-4-2 formation of sorts that will stay allow Solskjaer to include his favoured midfield trio of Paul Pogba, Ander Herrera and Nemanja Matic.
Elsewhere, Valencia and Darmian are still nursing injuries and Rojo is a long-term absentee, but Chris Smalling and Phil Jones will be pushing for recalls in the heart of defence.
Solskjaer must also decide whether to stick with Sergio Romero in goal at the expense of David de Gea, having used his second-choice keeper in both rounds so far.
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Who will win Monday's FA Cup clash between Chelsea and Manchester United?