Manager David Moyes has made a total of six changes after seeing his side beat Aston Villa 4-1 on Saturday as Antonio Valencia, Danny Welbeck, Alexander Buttner and Danny Welbeck are all given the nod.
Meanwhile, Bayern coach Pep Guardiola has made six changes to his starting XI following last weekend's 3-3 draw with Hoffenheim as Manuel Neuer, Philipp Lahm, Arjen Robben, Javi Martinez, Thomas Muller and David Alaba all come back in.
Mario Gotze and Mario Mandzukic both have to settle for a place on the bench for the Germans.
Man Utd: De Gea; Jones, Ferdinand, Vidic, Buttner; Valencia, Carrick, Fellaini, Giggs, Rooney; Welbeck
Subs: Lindegaard, Hernandez, Nani, Young, Fletcher, Januzaj, Kagawa
Bayern: Neuer; Rafinha, Martinez, Boateng, Alaba; Lahm, Schweinsteiger, Ribery, Kroos, Robben; Muller
Subs; Starke, Van Buyten, Mandzukic, Shaqiri, Pizarro, Gotze, Hojbjerg
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