The Red Devils go into the match against Olympiacos trailing 2-0 from the opening leg in Greece three weeks ago.
However, despite that deficit, the full-back has insisted that "anything is possible".
"Of course everybody knows it will be hard after the first result but it is definitely not impossible. We just need to play differently to how we did in the first game and be more adventurous," he told United Review.
"We are playing at Old Trafford and, with our supporters behind us, anything is possible. We just need to work hard and attack as often as possible."
In Olympiacos's two previous visits to Old Trafford, United have won 3-0 and 4-0.