The United manager also praised Madrid's form in recent weeks, which has included back-to-back wins against Barcelona.
"It's a massive build-up. It is an occasion that you always want to have, that is the beauty of the Champions League. Tomorrow is one of the biggest matches," Ferguson told reporters at a press conference.
"Both teams are in form, Real put in two fantastic performances against Barcelona. They have found form at the right time. Whereas our form has been consistent for some time. For a European night, it does not get bigger than this. I don't think it will be a disappointment."
The two sides are level at 1-1 from the first leg.