Defenders Matija Nastasic and Aleksandar Kolarov replace Javi Garcia and Gael Clichy following last weekend's 3-2 defeat at Cardiff. Midfielder Yaya Toure will wear the captain's armband for the Citizens.
Meanwhile, Hull's lineup shows just one alteration from the XI that began their 1-0 win over Norwich.
Man City: Hart, Zabaleta, Kolarov, Nastasic, Lescott, Fernandinho, Toure, Silva, Aguero, Dzeko, Navas
Subs: Pantilimon, Clichy, Negredo, Milner, Nasri, Garcia, Jovetic
Hull: McGregor, Figueroa, Chester, Davies, Elmohamady, Huddlestone, Koren, Livermore, Brady, Aluko, Graham
Subs: Harper, McShane, Bruce, Rosenior, Meyler, Boyd, Quinn