Lyon manager Hubert Fournier has made five changes ahead of his side's Champions League Group H clash against Valencia at the Stade de Gerland.
The Les Gones chief has dropped striker Claudio Beauvue to the bench, with Aldo Kalulu taking his place in the Ligue 1 side's starting XI.
Lyon, who lost 3-1 to Bordeaux at the weekend, are without the likes of Clement Grenier, Nabil Fekir and a host of defenders including Mapou Yanga-Mbiwa through injury.
Meanwhile, Valencia boss Nuno Espirito Santo makes three changes to his side, with Javi Fuego, Aymen Abdennour and Pablo Piatti all coming into the starting XI, while Andre Gomes and Jose Gaya are sidelined with injury.
Lyon: Lopes, Jallet, Bisevac, Umtiti, Morel, Gonalons, Darder, Tolisso, Valbuena, Kalulu, Lacazette
Subs: Gorgelin, Beauvue, Ghezzal, Ferri, Malbranque, Cornet, Mvuemba
Valencia: Domenech, Cancelo, Orban, Mustafi, Abdennour, Feghouli, Perez, Fuego, Parejo, Piatti, Negredo
Subs: Yoel, Santos, Barragan, Danilo, Mina, Rodrigo, Alcacer
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