While neither nation can qualify for next year's World Cup in Brazil, this encounter does hold significance for both teams because the loser will end the evening bottom of the standings.
Meanwhile, the hosts are likely to include Aurelien Joachim in their starting lineup following his goal against Russia last time out.
The last time these two sides met was a year ago at Windsor Park when a late goal from Daniel da Mota sealed a 1-1 draw for Luxembourg.
Northern Ireland: DDDLWL
Possible starting lineups
Luxembourg: Joubert; Philipps, Gerson, Payal, Janisch; Bensi, Laterza, Jans, Da Mota; Joachim, Turpel
Northern Ireland: Carroll; Hodson, Ferguson, McAuley, J Evans; McGinn, Davis, Paterson, C Evans, Norwood; Ward
Sports Mole says: 1-1