While Champions League qualification is a somewhat distant hope for the Reds, they could secure a place in next season's Europa League if they manage to close the current five-point gap to fifth.
The striker, who netted a brace in last weekend's 3-1 win over West Bromwich Albion, will be ineligible to play against the Reds as he is only at Upton Park on a loan deal from Merseyside.
The Hammers are expected to retain their Premier League status due to stretching six points above the relegation zone, so avenging their 3-2 defeat to the Reds in the reverse fixture will be at the forefront of their minds.
West Ham: WLWLL
Possible starting lineups
Liverpool: Reina; Johnson, Carragher, Agger, Enrique; Gerrard, Lucas; Coutinho, Henderson, Downing; Suarez
West Ham: Jaaskelainen; Demel, Reid, Collins, O'Brien; Diame, O'Neil; Jarvis, Nolan, Vaz Te; Cole
Sports Mole says: 2-0