Brendan Rodgers's men have lost their last two matches in the Premier League, and needed a 30-shot penalty shootout to get past Championship side Middlesbrough in the Capital One Cup earlier this week.
Three defeats from their last four outings in the top flight have left them 11th in the table, seven points behind league leaders Chelsea.
Philippe Coutinho and Jordan Henderson both missed the League Cup outing with injuries, and are due to undergo assessments ahead of Saturday's match to determine whether they will be able to play a role.
Meanwhile, the Toffees have just one Premier League win under their belts this season heading into the clash with their neighbours.
There was some good news for the manager from the trip to the Liberty Stadium though, as defender Bryan Oviedo played almost an hour in his first match since sustaining a double leg break in January.
The Costa Rica international could feature this weekend, while Arouna Kone, who was named on the bench on Tuesday, and Steven Pienaar could also be in line for returns, but Seamus Coleman's involvement remains in doubt.
Liverpool have a good record against their local rivals in recent seasons, with two wins and three draws from their last five meetings, including a 4-0 win at Anfield last season.
Possible starting lineups
Liverpool: Mignolet, Manquillo, Moreno, Lovren, Skrtel, Gerrard, Suso, Lucas, Sterling, Borini, Balotelli
Everton: Howard, Baines, Stones, Gibson, Jagielka, McCarthy, Barry, Mirallas, Osman, Lukaku, Atsu
Sports Mole says: 1-1