The Reds face successive home games against Manchester City, Manchester United and Arsenal, and the 29-year-old has called for the club to make Anfield a fortress.
"We don't have the easiest run of fixtures coming up, but they are what they are. We have to face them and I'm sure for them it won't be easy to come to Anfield. We have to make ourselves strong at home. This year we have to get better results at home," Reina told the Liverpool Echo.
Reina made 42 appearances for Liverpool last season.