"It can be difficult but it depends on the relationship between the manager and the director of football," Redknapp told talkSPORT.
"If you're both on the same wavelength and you want the same thing then I don't think it is such a problem. I couldn't work under those circumstances. If someone is choosing your players and they're no good then you are going to get the sack.
"The manager picks the team, trains the players every day and you've got to be the one that is making the big decisions. If your chairman is okay to work with then you don't need that middle man there."
Comolli was previously director of football at Spurs and was involved in the deal that brought Gareth Bale to White Hart Lane.