The Uruguayan took his Premier League goals tally to 22 on Sunday after helping the Reds to a 3-2 win over Tottenham Hotspur at Anfield.
Enrique admits that the Merseysiders heavily rely on "best player" Suarez, as they push for a place in next season's Champions League.
"In the game all the time the first person I look for is [Suarez] and he always makes a movement and I try to put the ball there and he does the rest," Enrique told Sky Sports News.
"It is really easy to understand with him. He is our best player and he can do something from nothing.
"It's like at Barcelona - the first player they look for when the game is in a bad situation is Messi because you know he can do something. Luis is the same - I look for him because I know he can do something different and we understand each other."
Liverpool travel to Southampton on Saturday.