Liverpool travel to White Hart Lane tomorrow boasting the Premier League's in-form striker, with the Uruguayan hitting 15 goals for the Reds this season - including four in the 5-1 demolition of Norwich City a fortnight ago.
Speaking to reporters, the Portuguese coach concedes it will be "very difficult" to stop the striker from adding to his haul.
Villas-Boas said: "He's a player going through a wonderful individual moment. He's full of the confidence. We have to be aware of his strengths. He's a player that individually can solve the game.
"So we have to be aware not only of the people that feed him but the actual individual moments of brilliance that we saw this season, that have been so decisive for Liverpool.
"He's a key player for them and very difficult to stop."
Tomorrow's clash in North London is scheduled to kick off at 4pm.