Liverpool suffered their first defeat of this season's group stage as they went down 3-2 to Udinese in a thrilling encounter at Anfield. Meanwhile, Anzhi Makhachkala moved to the top of the group with a comfortable 2-0 win at home to Young Boys, who remain pointless.
It took a late goal from Cristian Rodriguez to help Atletico Madrid see off Viktoria Plzen 1-0 at the Estadio Vicente Calderon, while Academica picked up their first point of the competition with a 1-1 draw at home to Hapoel Tel Aviv.
Newcastle United are up to second in Group D thanks to their 3-0 triumph over Bordeaux at the Sports Direct Arena. They are now two points behind Brugge following the Belgian side's 2-0 win over Maritimo.
Molde remain top of their group with a 2-0 victory against Stuttgart and Steaua Bucharest recorded their first win as they edged past FC Copenhagen 1-0.
Dnipro Dnipropetrovsk narrowly defeated AIK Solna 3-2 in Sweden to stay top of Group F, but Napoli lost ground on the Ukrainians after they were soundly beaten 3-0 away to PSV Eindhoven.
Leaders Genk squandered a two-goal lead to draw 2-2 at Basel in Group G, while Videoton got off the mark by brushing aside Sporting Lisbon 3-0 in Hungary.
Inter Milan are still unbeaten in the competition this season thanks to a 3-1 win over Azerbaijanis Neftchi Baku. Second-placed Rubin Kazan are behind the Italians on goal difference as they disposed of Partizan Belgrade 2-0.
Lyon earned a dramatic 4-3 win over Hapoel Ironi Kiryat Shmona in Israel to keep themselves top of Group I as Sparta Prague downed Athletic Bilbao 3-1 to open up the standings.
Matalist Kharkiv top their group after a 2-0 victory over Rapid Vienna, with Bayer Leverkusen winning for the first time against Rosenborg 1-0 in Denmark.
Hannover's 2-1 win at home to Levante has seen the Germans move top of Group L, while Helsingborg and FC Twente battled it out in a 2-2 draw in Sweden.