The O's, who start the game in 19th place in the table, have a lengthy injury list with Romain Vincelot (knee), Adam Legzdins (finger), David Mooney (ankle) and Lloyd James (leg) all missing for the visit of the Sky Blues.
Coventry, who are two places above Orient, make three changes to the side which beat Peterborough United last weekend.
Conor Thomas is missing for the visitors after picking up a fifth yellow card of the season.
Leyton Orient: Woods, Omozusi, Cuthbert, Baudry, Cox, McAnuff, Clarke, Wright, Bartley, Simpson, Plasmati
Coventry City: Burge, Willis, Johnson, Martin, Haynes, O'Brien, Finch, Barton, Fleck, Nouble, Madine