The Foxes will return to the top flight for the first time since 2004 if they beat Wednesday and Queens Park Rangers lose to Bournemouth the following day.
Meanwhile, a fourth win in six matches for the 14th-placed Owls would see the visitors edge closer towards the top half of the table.
Wednesday earned a surprise 2-1 victory over Leicester when the two teams met at Hillsborough back in December.
Possible starting lineups
Leicester: Schmeichel; De Laet, Konchesky, Morgan, Hammond; Moore, Dyer, Knockaert, King; Wood, Nugent
Wednesday: Kirkland; Buxton, Loovens, Onyewu, Mattock; Lee, Palmer, Maguire, Helan; Best, Afobe
Sports Mole says: 2-0