The Owls currently sit in the bottom three of the league table after taking just eight points from 10 matches this season but manager Dave Jones could witness a turnaround if his men overcome Neil Warnock's Leeds side.
The Whites can move into the playoff places if they snatch three points at the Hillsborough stadium on Friday as they hope to build on their five-match unbeaten run.
Sheffield Wed: LLLDL
Possible starting lineups:
Sheffield Wed: Kirkland; Buxton, Gardner, Llera, Mattock; Antonio, Semedo, McCabe, Barkley; O'Grady, Bothroyd
Leeds: Kenny; Byram, Lees, Pearce, Peltier; Brown, Austin, Tonge, White; Becchio, Diouf
Sports Mole says: 0-2