That defeat was on the back of their stunning triumph over Arsenal in the FA Cup last weekend and Appleton could decide to shuffle his pack against Leeds.
However, the pressure eased on the former Queens Park Rangers boss after Leeds recorded a 2-0 win over Blackpool on Wednesday night.
That result took Leeds to within six points of the Championship playoffs and barring any late injury issues, Warnock is likely to make no changes to his side.
Blackburn Rovers: WWWDWL
Leeds United: WLDLLW
Possible starting lineups
Blackburn Rovers: Kean; Orr, Mn.Olsson, Dann, G.Hanley; Bentley, Lowe, Murphy, Williamson; Rhodes, Campbell
Leeds United: Kenny; Peltier, Lees, Warnock, Byram; Green, Varney, Tonge, Norris; Morison, McCormack
Sports Mole says: 3-1