The Biancocelesti have not won in their last six league fixtures, and lost their last two games before claiming a goalless draw in the Europa League against Trabzonspor in midweek.
They are currently 12th in the table, and sit 10 points behind Fiorentina, who are in the last European qualifying place.
Livorno have struggled in the league since winning promotion to the top flight last season, and ended a run of three defeats in a row last weekend, by holding AC Milan to a 2-2 draw.
They are 18th in the table, having collected 13 points so far this season, and have only won one of their seven games away from home.
Possible starting lineups
Lazio: Konko, Dias, Biava, Radu, Ledesma, Onazi, Ederson, Candreva, Keita, Lulic, Klose
Livorno: Bardi, Coda, Emerson, Ceccherini, Schiattarella, Lights, Duncan, Greek, Mbaye, Siligardi, Paulinho
Sports Mole says: 2-0