The clash between Galaxy and Houston Dynamo at the Home Depot Center will be the 37-year-old's last fixture for the American club.
"I've had an incredibly special time playing for the LA Galaxy, however, I wanted to experience one last challenge before the end of my playing career," said Beckham.
"I don't see this as the end of my relationship with the league as my ambition is to be part of the ownership structure in the future.
"In my time here I have seen the popularity of the game grow every year. I've been fortunate to win trophies, but more important to me has been the fantastic reception I've had from fans in LA and across the States. Soccer's potential has no limits in this wonderful country, and I want to always be part of growing it."
Beckham joined Galaxy from Real Madrid in 2007 and won the MLS Cup in 2011.