Indeed, 13 points currently separate leaders Juve from second-placed Napoli, meaning that only a win will do for the home side as they desperately look to claw back some ground on Massimiliano Allegri's side.
It is difficult to be too critical of Napoli when considering that they have won 17 of their 25 league matches this season, suffering just three defeats to collect 56 points.
Carlo Ancelotti's side are nine points clear of third-placed Inter Milan, but trail Juve by 13 points due to the incredible form shown by the Italian champions, who are yet to lose in the league this term.
Since Juve won the reverse fixture 3-1 back in September, Napoli have only lost once in the league, with that defeat coming away at Inter Milan on Boxing Day. Their form in 2019 has been good, although three draws in their last five league matches has allowed Juve to pull clear at the summit.
Indeed, between January 26 and February 17, Napoli drew 0-0 on three occasions in the league, starting with AC Milan before sharing the points away to Fiorentina and at home to Torino.
The Naples club recorded a 4-0 victory away to Parma last weekend, though, and will be desperate to overcome Juve on Sunday evening, even if the result does little to harm Allegri's side in the long run.
No team have conceded fewer home Serie A goals than the Blues this term, having shipped just seven in their 13 matches, winning 10 of those and remaining unbeaten in the process.
Napoli have not actually beaten Juve in a home Serie A fixture since September 2015, but they did record a 1-0 win over the Old Lady in Turin last season and certainly have the credentials to harm the reigning champions.
Failing to progress into the last-16 stage of this season's Champions League was a huge disappointment for the Italian giants, but they will be keen to challenge for the Europa League and will take on Red Bull Salzburg in the next round of the competition.
It seems almost impossible to imagine Juve losing the title from this position, but a win for Napoli on Sunday night would certainly make it slightly more interesting in the race for the crown.
Recent form: WDWDDW
Recent form (all competitions): WDWDWW
Last weekend's 1-0 victory over Bologna made it 22 league wins for the campaign, leaving Juve clear at the summit. Allegri's side, as mentioned, are yet to taste defeat in the league this term and have both the best offensive and defensive records this term, scoring 53 times and conceding just 15.
However, the mood in the camp is not all smiles at the moment. Indeed, it would be fair to say that the Champions League is the trophy that Juve really want this season, but they face a huge task to make the quarter-finals following a 2-0 defeat at Atletico in the first leg of their last-16 tie at the Wanda Metropolitano.
There will be no Coppa Italia for Juve this season, meanwhile, following their shock 3-0 loss to Atalanta BC at the end of last month. Should they fail to turn their last-16 tie around against Atletico on March 12 then they will be left with just the league title, which would not be considered a good campaign.
Before facing Atletico, Juve have two Serie A matches. Indeed, they will visit Napoli on Sunday night before welcoming Udinese next Friday ahead of the clash with Diego Simeone's side the following Tuesday.
Juve have comfortably the best away record in Italy's top flight this season, having won 11 and drawn one of their 12 games on their travels. It really has been a stunning league campaign thus far and they would effectively secure the title with a victory in Naples this weekend.
Allegri has been in charge of Juve since 2014, winning an incredible four Serie A crowns, four Coppa Italia trophies and two Supercoppa Italiana titles since arriving at the club.
The 51-year-old has also led the team to two Champions League finals, but as mentioned above, the Old Lady face a big task to progress to the quarter-finals of this season's competition.
For now, though, their focus has to be on what is shaping up to be a fascinating clash with Ancelotti's team.
Recent form: WWDWWW
Recent form (all competitions): LDWWLW
Lorenzo Insigne is back in the Napoli squad after suspension ruled him out of the clash with Parma last time out.
Kalidou Koulibaly is widely regarded as one of the best centre-backs in world football, and the Manchester United target will be looking to put on a strong showing against the league leaders.
Cristiano Ronaldo had been seen as a huge doubt for Juve due to ankle problem, but the Portugal international has been declared fit and will start in the final third of the field.
Napoli possible starting lineup:
Meret; Malcuit, Maksimovic, Koulibaly, Hysaj; Callejon, Fabian Ruiz, Allan, Zielinski; Milik, Insigne
Juventus possible starting lineup:
Szczesny; De Sciglio, Bonucci, Chiellini, Sandro; Bentancur, Pjanic, Matuidi; Dybala, Mandzukic, Ronaldo
Head To Head
Juve recorded a 3-1 victory in the reverse match earlier this season, while the Old Lady also ran out 1-0 winners when they travelled to Naples for the corresponding clash last term.
Napoli's last home league victory over Juve came in September 2015, while the team from Turin have won six of their last nine Serie A meetings, suffering just two defeats in the process.
We say: Napoli 1-1 Juventus
Napoli have been very strong at home this season and we fancy Ancelotti's side to hold Juve to a low-scoring draw, which the visitors would surely take due to their position in the table.