The Azzurri kick-started their World Cup campaign with a victory in their Group D opener courtesy of Balotelli's second-half header.
Prandelli was full of praise for the way his whole team coped with the sweltering heat in Manaus, but singled out the AC Milan hitman for special credit.
"It was impossible to maintain that level of intensity [in the heat]. The team suffered, but we maintained the supremacy in the middle of the field," he told Rai Sports
"We worked well in training and it showed, as midway through the second half England's players had cramp. It means our work paid off.
"Balotelli gave everything he possibly could've given. Everyone gave their all."
Italy resume World Cup duties by facing Costa Rica on Thursday.