The Azzuri coach thinks that victory over the Danes in Milan could go a long way towards securing a place on the plane to Brazil in 2014.
Prandelli told reporters at the pre-match press conference: "I have respect for the press, but from home it's difficult to judge a football match. I don't want to give any advantage to the opponents.
"Denmark are a well-organised team, but we need the three points. If we can manage to earn those it would be an important step in a very balanced group."
Italy are top of Group B after taking seven points from their opening three qualifying matches, while Denmark have drawn their first two group games.