McCarthy's Blues have slipped into the bottom half of the table after four games without a win in the league.
Three of those were away from home though and the Tractor Boys' record is better at Portman Road, where they have won four of six in the league this season.
Opponents Barnsley go into the match sitting in lowly 23rd place.
Both matches between the pair finished as 1-1 draws last season.
Possible starting lineups
Ipswich: Gerken; Chambers, Berra, Smith; Cresswell; Anderson, Skuse, Hyam, Tunnicliffe; Murphy, McGoldrick
Barnsley: Butland; Kennedy, Cranie, M'voto, Wiseman; McCourt, Perkins, Fox, Mellis; O'Grady, Pedersen
Sports Mole says: 3-1