Walter Mazzarri's men are six points adrift of Juventus and Napoli in fourth place following a run of two wins from their last six matches, but did produce an impressive 3-0 success at Udinese last time out.
Livorno, meanwhile, can travel to the San Siro with confidence after claiming just their third win of the campaign over Atalanta last weekend, but are likely to be without attacking midfielder Luca Belingheri with a calf injury.
Possible starting lineups
Inter: Handanovic, Juan Jesus, Ranocchia, Nagatomo, Samuel, Taider, Cambiasso, Guarin, Jonathan, Alvarez, Palacio
Livorno: Bardi, Ceccherini, Coda, Rinuardo, Mbaye, Luci, Emerson, Greco, Gemitri, Paulinho, Emeghara
Sports Mole says: 2-0