Andrea Stramaccioni's men have been solely focused on their league campaign after they were dumped out of the Europa League at the hands of Tottenham Hotspur.
In contrast, Atalanta have failed to snatch a win in their last two encounters, but are expected to avoid the drop from the top flight due to their eight-point gap from the bottom three.
Inter Milan: WLWLL
Possible starting lineups
Inter Milan: Handanovic; Zanetti, Ranocchia, Juan, Jonathan; Pereira, Kovacic, Guarin, Gargano; Palacio, Cassano
Atalanta: Consigli; Stendardo, Lucchini, Canini, Del Grosso; Bonaventura, Moralez, Cigarini, Raimondi, Biondini; Denis
Sports Mole says: 2-0