The hosts are currently on a five-match unbeaten streak which has seen them almost to safety - three draws and two wins have come from those games.
Inter's defeat to Lazio on Wednesday night has consigned them to their highest loss tally in their Serie A history and as such they are now unable to qualify for Europe.
Aside from Genoa's long-term absentees the only fresh concern is over left-back Luca Antonelli, who faces a battle to be fit for the game.
Possible starting lineups
Genoa: Frey; Portanova, Manfredini, Moretti, Antonelli; Cassani, Matuzalem, Kucka, Rigoni; Bertolacci, Borriello
Inter: Handanovic; Jonathan, Ranocchia, Juan Jesus, Pereira; Cambiasso; Kovacic, Kuzmanovic, Guarin; Alvarez, Rocchi
Sports Mole says: 2-1