Goals from Alessandro Florenzi and Mattia Destro handed the home side an advantage in the opening leg, but the tie remains very much in the balance with Inter now playing in front of their own supporters.
Inter overcame Bologna in the previous round to advance to this stage of the competition, while Roma were 1-0 winners against Fiorentina. The victor of Wednesday's clash will face Lazio in the final, who were victorious over Serie A leaders Juventus.
In terms of the recent meetings between the two sides, Roma have enjoyed the better of it with three wins from the last five matches against Inter, with the other two ending in draws. However, there is just one point separating fifth-placed Roma from seventh-placed Inter in the league table.
The home side have no fresh injury concerns ahead of the match, but Walter Samuel and Yuto Nagatomo are both pushing for starts in defence. Esteban Cambiasso is also fit, but Niccolo Belloni is expected to remain on the bench.
Roma, meanwhile, could recall Francesco Totti to their starting side, with either Erik Lamela or Pablo Osvaldo dropping to the bench. Marquinho is also pushing for a recall, but is expected to remain on the bench alongside Destro.
Inter Milan: WLWLL
Inter Milan: Handanovic; Zanetti, Silvestre, Pereira, Juan; Kovacic, Alvarez, Guarin, Cambiasso, Gargano; Rocchi
Roma: Stekelenburg; Castan, Piris, Dodo, Burdisso, Balzaretti; Bradley, Pranjic, Perotta; Lamela, Totti
Sports Mole says: 1-1