The Irish international, 25, is expected to make his debut for the visitors following his recent move from West Bromwich Albion.
Despite admitting that Palace will provide difficult opposition, Long is confident that Hull can get a positive result in the capital.
"It's not an easy place to go," he told the club's official website.
"They've picked up a lot of wins lately so it's going to be a tough game, we're under no illusions, but we have that quality that we can go out there and get the three points if we turn up on the night. We've got to make sure that we do that."
Hull make the trip to Selhurst Park on the back of three consecutive defeats in the Premier League.