The midfielder, a summer signing from Norwich City, suffered a dislocated knee cap on the opening day of the new campaign, ruling him out for at least six months.
Bruce told FourFourTwo: "It looks as though he will be out for six months, but in my experience that practically rules you out for the season.
"It's six months, then probably two months of rehab. If I'm being honest, I doubt we'll see him until next pre-season.
"It's devastating for him and for us. A lot was invested in him to give us something a little bit different from midfield. It's tough luck, but that's football."
Hull face Stoke City in the Premier League at the KC Stadium tomorrow afternoon.