Former England midfielder Scott Parker is back to captain the Whites against his former club in midfield, while Tim Hoogland replaces Elsad Zverotic at right-back for the London derby at Craven Cottage.
Victory for Fulham, who have picked up 10 points from 18 games since the sacking of Felix Magath, will improve Symons's chances of landing the job on a full-time basis and lift them out of the relegation zone.
Fulham: Bettinelli; Hoogland, Bodurov, Burn, Stafylidis; Parker; Christensen, Kavanagh; Ruiz; Rodallega, McCormack
Subs: Kiraly, Hutchinson, Zverotić, Roberts, Williams, Woodrow, Smith
Charlton: Henderson, Solly, Fox, Ben Haim, Bikey, Wilson, Jackson, Cousins, Bulot, Moussa, Tucudean
Subs: Pope, Morrison, Gudmudsson, Harriott, Munns, Thomas, Ahearne-Grant
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