Dempsey, 28, has scored 15 goals in 30 appearances for the Cottagers this season, and Jol has praised the midfielder's form.
"Clint has been the difference for us, but every team relies on productive players. Even Barcelona are not the same without players who can make the difference – and Clint is certainly that," Jol told The Sun.
"Hopefully someone else can score if they try and stop Clint. We have goals from other places."
Fulham travel to Everton in the FA Cup on Friday evening.