Four of the six nations in Group H can still qualify automatically for next year's World Cup in Brazil.
Two of them, England and Montenegro, will meet at Wembley on Friday night. The home side currently top the group with 16 points and if they emerge victorious, then it will end Montenegro's chances of finishing at the summit.
However, should Branko Brnovic's team win, then they would leapfrog the Three Lions and could even replace them at the top of the standings, depending on the Ukraine against Poland result.
Also, Daniel Sturridge's positive start to the season with Liverpool could earn him a place up front alongside Wayne Rooney, which would mean that Danny Welbeck has to settle for a place among the substitutes.
These two teams have met on three previous occasions, all of which have ended in draws.
What's more, England have not lost a competitive fixture in 90 minutes since their defeat to Germany at the 2010 World Cup, although they went down on penalties to Italy at Euro 2012.
Possible starting lineups
England: Hart; Walker, Cahill, Jagielka, Baines; Lampard, Gerrard, Milner, Wilshere; Rooney, Sturridge
Montenegro: Bozovic; Basa, Džudovic, Bozovic, Savic; Zverotic; Boskovic, Drincic, Krkotic; Jovetic; Vucinic
Sports Mole says: 1-0