The Three Lions defeated Moldova 5-0 in the reverse fixture in Chisinau back in September last year, but Hodgson is not taking anything for granted.
Following the Moldova clash, England will take on Ukraine on Tuesday in a bid to boost their chances of qualifying for the World Cup in Brazil next year.
"The four remaining games are of vital importance," Hodgson said in a press conference. "I don't quantify games as one being easy or one being hard.
"Moldova have proven very hard to beat and we know they will be hard to beat on Friday night and I will need my best players. I think we need 10 points. I think that would see us mathematically certain."