The duo will star alongside Karim Bellarabi, as Lars Bender will continue to feature in midfield for Bayer.
Hosts Eintracht have opted for Olivier Occean and Alexander Meier as the front duo, with Kevin Trapp in goal.
Pirmin Schwegler, Sebastian Rode, Takashi Inui and Stefan Aigner will feature in midfield for the home side.
Eintracht Frankfurt: Trapp, Anderson, Zambrano, Oczipka, Jung, Schwegler, Rode, Inui, Aigner, Occean, Meier
Bayer Leverkusen: Leno, Wollscheid, Toprak, Kadlec, Schwaab, Reinartz, Rolfes, Bender, Bellarabi, Keissling, Schurrle