The Lions have endured a poor second half to the campaign and go into their final match two points above the drop zone.
A draw is also likely to be good enough for the away side to stay up, but a defeat will give Barnsley a chance to overtake them in the standings.
Derby, who could finish the season as high as 10th place, are expected to welcome back Paul Coutts.
Derby: Legzdins; Brayford, Keogh, Buxton, Forsyth; Bryson, Hendrick, Hughes, Ward; Sammon, Martin
Millwall: Forde; Dunne, Shittu, Beevers, Lowry; Feeney, St Ledger, Wright, Henry, Batt; Keogh
Sports Mole says: 1-1