The Blues currently sit two points behind fourth-placed Manchester United with a game in hand over both United and fifth-placed Arsenal, who face each other later in the day on Sunday.
It could be a profitable weekend for Maurizio Sarri's side as they look to secure a return to Champions League action next season, then, but they take on a team leading the race to be the 'best of the rest' in seventh.
Here, Sports Mole looks at how Sarri could set his team out for the match.
Out: Marco van Ginkel (knee)
Sarri boasts a clean bill of health at the moment, and that should make his starting XI relatively predictable with plenty of familiar faces set to return after the midweek Europa League win over Dynamo Kiev.
The Italian must decide who to start as his third man in midfield, and Ross Barkley's withdrawal just past the hour mark on Thursday night suggests that he has the edge over Mateo Kovacic, who played the full 90 minutes.